KLRA2 (also known as Ly49B) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA2 is thought to be an inhibitory receptor and associates with the protein tyrosine phosphatases SHP1, SHP2, and SHIP in transfected cells. This antibody is predicted to not cross-react with other LY49 receptors.
killer cell lectin-like receptor 2; killer cell lectin-like receptor subfamily A member 30; killer cell lectin-like receptor, subfamily A, member 2; Klra30, Ly49b; ly-49b; Ly49 inhibitory receptor 6; lymphocyte antigen 49b; membrane protein Ly49b; NK cell inhibitory receptor Klra2; T-cell surface glycoprotein Ly-49B; T-cell surface glycoprotein Ly49b