The gene encoding PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.
cadherin-related neuronal receptor 1; Cadherin-related neuronal receptor 4; CNR1; CNRN1; CRNR1; KIAA0345-like 10; MGC138307; MGC142169; ortholog of mouse CNR1; PCDH-alpha-4; PCDH-ALPHA4; Protocadherin alpha 4; Protocadherin alpha-4