The Toll-like Receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drospphila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR12 has been cloned that displays a distinct pattern of expression in macrophages and liver, kidney and bladder epithelial cells. TLR12 does not respond to known TLR ligands.
Gm287; MGC129352; MGC129353; Toll-like receptor 11; Toll-like receptor 12