Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis.
Alpha-trypsin chain 1; Alpha-trypsin chain 2; Anionic trypsinogen; Beta-trypsin; Brain trypsinogen; Cationic trypsinogen; digestive zymogen; Mesotrypsin; Mesotrypsinogen; nonfunctional trypsin 1; pancreatic trypsinogen III; protease serine 2 preproprotein; protease, serine, 2 (trypsin 2); protease, serine, 4 (trypsin 4, brain); Serine protease 1; Serine protease 2; Serine protease 3; Serine protease 4; TCR V beta 4.1; Trypsin I; Trypsin II; Trypsin III; Trypsin IV; Trypsin-1; Trypsin-2; Trypsin-3; trypsinogen 1; trypsinogen 2; trypsinogen 4; trypsinogen 5; trypsinogen A; trypsinogen IV