Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: FAESGTARK TLHFEISKEG SDLSVVERAE VWLFLKVPKA NRTRTKVTIR LFQQQKHPQG SLDTGEEAEE VGLKGERSEL LLSEKVVDAR KSTWHVFPVS SSIQRLLDQG KSSLDVRIAC EQCQESGASL VLLGKKKKKE EEGEGKKKGG GEGGAGADEE KEQSHRPFLM LQARQSEDHP HRRRRRGLEC DGKVNICCKK QFFVSFKDIG WNDWIIAPSG YHANYCEGEC PSHIAGTSGS SLSFHSTVIN HYRMRGHSPF ANLKSCCVPT KLRPMSMLYY DDGQNIIKKD IQNMIVEECG CS (126-426 aa encoded by BC007858)
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
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