Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MEEIGILVE KAQDEIPALS VSRPQTGLSF LGPEPEDLED LYSRYKKLQQ ELEFLEVQEE YIKDEQKNLK KEFLHAQEEV KRIQSIPLVI GQFLEAVDQN TAIVGSTTGS NYYVRILSTI DRELLKPNAS VALHKHSNAL VDVLPPEADS SIMMLTSDQK PDVMYADIGG MDIQKQEVRE AVELPLTHFE LYKQIGIDPP RGVLMYGPPG CGKTMLAKAV AHHTTAAFIR VVGSEFVQKY LGEGPRMVRD VFRLAKENAP AIIFIDEIDA IATKRFDAQT GADREVQRIL LELLNQMDGF DQNVNVKVIM ATNRADTLDP ALLRPGRLDR KIEFPLPDRR QKRLIFSTIT SKMNLSEEVD LEDYVARPDK ISGADINSIC QESGMLAVRE NRYIVLAKDF EKAYKTVIKK DEQEHEFYK (1-418 aa encoded by BC014488 )
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
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Protein Aliases: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP21; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; Proteasome 26S subunit ATPase 4; S6 ATPase; TAT-binding protein 7; TBP-7
Gene Aliases: CIP21; MIP224; PSMC4; RPT3; S6; TBP-7; TBP7
UniProt ID: (Human) P43686, (Rat) Q63570, (Mouse) P54775
Entrez Gene ID: (Human) 5704, (Rat) 117262, (Mouse) 23996
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