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Immunogen sequence: GSGCAWGAE PPRFLEAFGR LWQVQSRLGS GSSASVYRVR CCGNPGSPPG ALKQFLPPGT TGAAASAAEY GFRKERAALE QLQGHRNIVT LYGVFTIHFS PNVPSRCLLL ELLDVSVSEL LLYSSHQGCS MWMIQHCARD VLEALAFLHH EGYVHADLKP RNILWSAENE CFKLIDFGLS FKEGNQDVKY IQTDGYRAPE AELQNCLAQA GLQSDTECTS AVDLWSLGII LLEMFSGMKL KHTVRSQEWK ANSSATIDHI FASKAVVNAA IPAYHLRDLI KSMLHDDPSR RIPAEMALCS PFFSIPFAPH IEDLVMLPTP VLRLLNVLDD DYLENEEEYE GLC (3-344 aa encoded by BC026046)
Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: kinase interacting stathmin; kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; KIS protein kinase; P-CIP2; PAM COOH-terminal interactor protein 2; Serine/threonine-protein kinase Kist; U2AF homology motif kinase 1
Gene Aliases: 4732477C12Rik; 4930500M09Rik; AA673513; AI449218; AU021979; KIS; KIST; P-CIP2; UHMK1
UniProt ID: (Human) Q8TAS1, (Mouse) P97343, (Rat) Q63285
Entrez Gene ID: (Human) 127933, (Mouse) 16589, (Rat) 246332
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