Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PSRAQLQLH LPANRLQAVE GGEVVLPAWY TLHGEVSSSQ PWEVPFVMWF FKQKEKEDQV LSYINGVTTS KPGVSLVYSM PSRNLSLRLE GLQEKDSGPY SCSVNVQDKQ GKSRGHSIKT LELNVLVPPA PPSCRLQGVP HVGANVTLSC QSPRSKPAVQ YQWDRQLPSF QTFFAPALDV IRGSLSLTNL SSSMAGVYVC KAHNEVGTAQ CNVTLEVSTG PGAAVVAGAV VGTLVGLGLL AGLVLLYHRR GKALEEPAND IKEDAIAPRT LPWPKSSDTI SKNGTLSSVT SARALRPPHG PPRPGALTPT PSLSSQALPS PRLPTTDGAH PQPISPIPGG VSSSGLSRMG AVPVMVPAQS QAGSLV (26-390 aa encoded by BC016868)
ESAM is a 55-kDa membrane protein composed of 2 extracellular Ig domains, a single transmembrane domain, and a 120 amino acid cytoplasmic domain. ESAM is related to members of the junctional adhesion molecule (JAM) family, and is expressed on endothelial cells and activated platelets. ESAM at endothelial tight junctions plays a role in the regulation of vascular permeability, in response to agents such as VEGF or extravasating neutrophils.
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