Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: NIDYKKPLK VIFVGEDAVD AGGVRKEFFL LIMRELLDPK YGMFRYYEDS RLIWFSDKTF EDSDLFHLIG VICGLAIYNC TIVDLHFPLA LYKKLLKKKP SLDDLKELMP DVGRSMQQLL DYPEDDIEET FCLNFTITVE NFGATEVKEL VLNGADTAVN KQNRQEFVDA YVDYIFNKSV ASLFDAFHAG FHKVCGGKVL LLFQPNELQA MVIGNTNYDW KELEKNTEYK GEYWAEHPTI KIFWEVFHEL PLEKKKQFLL FLTGSDRIPI LGMKSLKLVI QSTGGGEEYL PVSHTCFNLL DLPKYTEKET LRSKLIQAID HNEGFSLI (723-1049 aa encoded by BC039600)
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HECT domain and RCC1-like domain-containing protein 4; hect domain and RLD 4; HECT-type E3 ubiquitin transferase HERC4; Probable E3 ubiquitin-protein ligase HERC4
Gene Aliases: 1700056O17Rik; 4921531D01Rik; 9530080M15Rik; HERC4; KIAA1593; mKIAA1593
UniProt ID: (Human) Q5GLZ8, (Mouse) Q6PAV2, (Rat) Q5PQN1
Entrez Gene ID: (Human) 26091, (Mouse) 67345, (Rat) 309758
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