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Immunogen sequence: MAATAREDG ASGQERGQRG CEHYDRGCLL KAPCCDKLYT CRLCHDNNED HQLDRFKVKE VQCINCEKIQ HAQQTCEECS TLFGEYYCDI CHLFDKDKKQ YHCENCGICR IGPKEDFFHC LKCNLCLAMN LQGRHKCIEN VSQQNCPICL EDIHTSRVVA HVLPCGHLLH RTCYEEMLKE GYRCPLCMHS ALDMTRYWRQ LDDEVAQTPM PSEYQNMTVD ILCNDCNGRS TVQFHILGMK CKICESYNTA QAGGRRISLD QQ (1-261 aa encoded by BC047393)
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.
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