Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: SGSLSAPPA ASVISAPPSS SSRHRKRRRT SSKSEAGARG GGQGSKEKGR GSWGGRHHHH HPLPAAGFKK QQRKFQYGNY CKYYGYRNPS CEDGRLRVLK PEWFRGRDVL DLGCNVGHLT LSIACKWGPS RMVGLDIDSR LIHSARQNIR HYLSEELRLP PQTLEGDPGA EGEEGTTTVR KRSCFPASLT ASRGPIAAPQ VPLDGADTSV FPNNVVFVTG NYVLDRDDLV EAQTPEYDVV LCLSLTKWVH LNWGDEGLKR MFRRIYRHLR PGGILVLEPQ PWSSYGKRKT LTETIYKNYY RIQLKPEQFS SYLTSPDVGF SSYELVATPH NTSKGFQRPV YLFHKARSPS H (340-689 aa encoded by BC000556)
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 7SK snRNA methylphosphate capping enzyme; Bicoid-interacting protein 3 homolog; Bin3 homolog; bin3, bicoid-interacting 3, homolog; FLJ20257; MePCE
Gene Aliases: BCDIN3; MEPCE
UniProt ID: (Human) Q7L2J0
Entrez Gene ID: (Human) 56257
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