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Immunogen sequence: QLHYSIPEE AKHGTFVGRI AQDLGLELAE LVPRLFRVAS KGRGDLLEVN LQNGILFVNS RIDREELCRR RAECSIHLEV IVDRPLQVFH VEVAVKDIND NPPRFSRQEQ RLFILESRMP DSRFPLEGAS DLDIGANAQL RYRLNPNEYF DLDVKTNEEE TNFLELVLRK SLDREETQEH RLLVIATDGG KPELTGTVQL LINVLDANDS APEFDKSIYN VRLLENAPSG TLVIKLNASD ADEGINKEIV YFFSNLVLDD VKSKFIINSN TGEIKVNGEL DYEDYNSYEI NIDAMDKSTF PLSGHCKVVV KLLDVNDNTP EMAITTLFLP VKEDAPLSTV IALISVSDRD SGANGQVTCS LMPHVPFKLV STF (29-400 aa encoded by BC033735)
The gene encoding PCDHA5 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA5 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA5 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.
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Protein Aliases: cadherin-related neuronal receptor 5; cadherin-related neuronal receptor 6; KIAA0345-like 9; ortholog of mouse CNR6; PCDH-alpha-5; Protocadherin alpha-5
Gene Aliases: CNR6; CNRN6; CNRS6; CRNR6; PCDH-ALPHA5; PCDHA5; rCNRv05
UniProt ID: (Human) Q9Y5H7
Entrez Gene ID: (Human) 56143, (Mouse) 12941, (Rat) 393087
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