Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
The WDR5 antibody targets the WD repeat protein domain 5 (WDR5), a member of the WD40 repeat protein family in humans.
Immunogen sequence: MATEEKKPE TEAARAQPTP SSSATQSKPT PVKPNYALKF TLAGHTKAVS SVKFSPNGEW LASSSADKLI KIWGAYDGKF EKTISGHKLG ISDVAWSSDS NLLVSASDDK TLKIWDVSSG KCLKTLKGHS NYVFCCNFNP QSNLIVSGSF DESVRIWDVK TGKCLKTLPA HSDPVSAVHF NRDGSLIVSS SYDGLCRIWD TASGQCLKTL IDDDNPPVSF VKFSPNGKYI LAATLDNTLK LWDYSKGKCL KTYTGHKNEK YCIFANFSVT GGKWIVSGSE DNLVYIWNLQ TKEIVQKLQG HTDVVISTAC HPTENIIASA ALENDKTIKL WKSDC (1-334 aa encoded by BC001635)
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3, Set1c WD40 repeat protein, homolog; WD repeat-containing protein 5; WD repeat-containing protein BIG-3
Gene Aliases: 2410008O07Rik; AA408785; AA960360; Big; BIG-3; BIG3; CFAP89; SWD3; WDR5
UniProt ID: (Human) P61964, (Mouse) P61965, (Rat) Q498M4
Entrez Gene ID: (Human) 11091, (Mouse) 140858, (Rat) 362093
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