Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: KSLGASRSR GILGKFVPPI PKQDGGEQNG GMQCKPYGAG PTEPAHPVDE RLKNLEPKMI ELIMNEIMDH GPPVNWEDIA GVEFAKATIK EIVVWPMLRP DIFTGLRGPP KGILLFGPPG TGKTLIGKCI ASQSGATFFS ISASSLTSKW VGEGEKMVRA LFAVARCQQP AVIFIDEIDS LLSQRGDGEH ESSRRIKTEF LVQLDGATTS SEDRILVVGA TNRPQEIDEA ARRRLVKRLY IPLPEASARK QIVINLMSKE QCCLSEEEIE QIVQQSDAFS GADMTQLCRE ASLGPIRSLQ TADIATITPD QVRPIAYIDF ENAFRTVRPS VSPKDLELYE NWNKTFGCGK (326-674 aa encoded by BC051867)
The mammalian Phospholipase Cg (PLCg) family has two closely related proteins, PLCg1 and PLCg2. The PLCg isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: fidgetin-like 1; Fidgetin-like protein 1
Gene Aliases: FIGNL1; S30
UniProt ID: (Human) Q6PIW4, (Rat) Q6GX84, (Mouse) Q8BPY9
Entrez Gene ID: (Human) 63979, (Rat) 289777, (Mouse) 60530
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support