Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MYGRPQAEM EQEAGELSRW QAAHQAAQDN ENSAPILNMS SSSGSSGVHT SWNQGLPTIQ HFPHSAEMLG SPLVSVEAPG QNVNEGGPQF SMPLPERGMS YCPQATLTPS RMIYCQRMSP PQQEMTIFSG PQLMPVGEPN IPRVARPFGG NLRMPPSGLP VSASTGIPIM SHTGNPPVPY PGLSTVPSDE TLLGPTVPST EAQAVLPSMA QMLPPQDAHD LGMPPAESQS LLVLGSQDSL VSQPDSQEGP FLPEQPGPAP QTVEKNSRPQ EGTGRRGSSE ARPYCCNYEN CGKAYTKRSH LVSHQRKHTG ERPYSCNWES CSWSFFRSDE LRRHMRVHTR YRPYKCDQCS REFMRSDHLK QHQKTHRPGP SDPQANNNNG EQDSPPAAGP (1-389 aa encoded by BC049844)
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ40160; Krueppel-like factor 17; Kruppel-like factor 17; novel zinc-finger protein; Zinc finger protein 393; ZLF393
Gene Aliases: KLF17; Zfp393; ZNF393
UniProt ID: (Human) Q5JT82
Entrez Gene ID: (Human) 128209
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