Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: TSDTKSDTA TGGESAGHAT SSQEPSGCSD QRPAEDLNIR VERLTKKLEE RREEKRKEEE QREIKKEIER RKTGKEMLDY KRKQEEELTK RMLEERNREK AEDRAARERI KQQIALDRAE RAARFAKTKE EVEAAKAAAL LAKQAEMEVK RESYARERST VARIQFRLPD GSSFTNQFPS DAPLEEARQF AAQTVGNTYG NFSLATMFPR REFTKEDYKK KLLDLELAPS ASVVLLPAGR PTASIVHSSS GDIWTLLGTV LYPFLAIWRL ISNFLFSNPP PTQTSVRVTS SEPPNPASSS KSEKREPVRK RVLEKRGDDF KKEGKIYRLR TQDDGEDENN TWNGNSTQQM (160-508 aa encoded by BC035594)
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its ocogenic activity. Serves as an ocogene or tumor supressor depending on the cell context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Erasin; UBX domain containing 2; UBX domain-containing 1; UBX domain-containing protein 2; UBX domain-containing protein 4
Gene Aliases: 1300013G12Rik; erasin; KIAA0242; mKIAA0242; UBXD2; UBXDC1; UBXN4
UniProt ID: (Human) Q92575, (Rat) Q5HZY0, (Mouse) Q8VCH8
Entrez Gene ID: (Human) 23190, (Rat) 304766, (Mouse) 67812
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