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Search Thermo Fisher Scientific
Immunogen sequence: LAVLQRDRI KLLFFDILVF LSVFLLFLLF LVDIMANNTT SLGSPWPENF WEDLIMSFTV SMAIGLVLGG FIWAVFICLS RRRRASAPIS QWSSSRRSRS SYTHGLNRTG FYGHSGCERR SNLSLASLTF QRQASLEQAN SFPRKSSFRA STFHPFLQCP PLPVETESQL VTLPSSNISP TISTSHSLSR PDYWSSNSLR VGLSTPPPPA YESIIKAFPD S (15-235 aa encoded by BC022556)
MYCT1 was initially identified as a novel target of the c-Myc oncogene in myeloid cells. It is a widely expressed nuclear protein whose overexpression can promote apoptosis, alteration of morphology, enhancement of anchorage-independent cell growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. MYCT1 binds to the promoters of several c-Myc-regulated genes and it has been suggested that the phenotypes seen in MYCT1-overexpressing cells are a result of the deregulation of these genes. RUNX1-ETO, a fusion protein made up of RUNX1 and ETO, is thought to deregulate the proliferation and responsiveness of human hematopoietic progenitor cells downstream of MYCT1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MT-MC1; myc target in myeloid cells 1; Myc target in myeloid cells protein 1; Myc target protein 1
Gene Aliases: 1110020B04Rik; AI225941; AI642973; MTLC; MTMC1; MYCT1
UniProt ID: (Human) Q8N699, (Mouse) Q8R411
Entrez Gene ID: (Human) 80177, (Mouse) 68632
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