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Product # 23101-1-AP specifically recognizes 85 and 94 kDa isoforms.
Immunogen sequence: PPRDDCYDS SSLPDDISVV KVEDSFEGER PGRRSKKIWL VPIDFDKLEI PQPDFEVPGA DCLLSKEQLR SIYESSLSIG NFASRLLVHL FPELFTHENL RKQYSCSGSL GKKQLDPSRI KLIRHYVQLL YPRAKNDRVW TLEFVGKLDE RCRRRDTEQR RSYQQQRKVH VPGPECRDLT SYAINPERFR EEFEGPPLPP ERSSKDFCKI PLDELVVPSP DFPVPSPYLL SDKEVREIVQ QSLSVGNFAA RLLVRLFPEL FTAENLRLQY NHSGACNKKQ LDPTRLRLIR HYVEAVYPVE KMEEVWHYEC IPSIDERCRR PNRKKCDILK KAKKVEK (493-828 aa encoded by BC131628 )
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BEN domain-containing protein 3
Gene Aliases: BEND3; KIAA1553
UniProt ID: (Human) Q5T5X7
Entrez Gene ID: (Human) 57673
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