Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: RAHLKECFE TLKRNIPNVD DKKTSNLSVL RTALRYIQSL KRKEKEYEHE MERLAREKIA TQQRLAELKH ELSQWMDVLE IDRVLRQTGQ PEDDQASTST ASEGEDNIDE DMEEDRAGLG PPKLSHRPQP ELLKSTLPPP STTPAPLPPH PHPHPHSVAL PPAHLPVQQQ QPQQKTPLPA PPPPPAAPAQ TLVPAPAHLV ATAGGGSTVI AHTATTHASV IQTVNHVLQG PGGKHIAHIA PSAPSPAVQL APATPPIGHI TVHPATLNHV AHLGSQLPLY PQPVAVSHIA HTLSHQQVNG TAGLGPPATV MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A (233-582 aa encoded by BC117563)
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.
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Protein Aliases: bHLHd3; Class D basic helix-loop-helix protein 3; MAX binding protein; Max-binding protein MNT; Max-interacting protein; MNT, MAX dimerization protein; Myc antagonist MNT; Protein ROX
Gene Aliases: BHLHD3; MAD6; MNT; MXD6; ROX
UniProt ID: (Human) Q99583
Entrez Gene ID: (Human) 4335
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