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Two bands at 130 kDa and 75 kDa could be detected using antibody 66033-1-Ig.
Immunogen sequence: MVQKESQAT LEERESELSS NPAASAGASL EPPAAPAPGE DNPAGAGGAA VAGAAGGARR FLCGVVEGFY GRPWVMEQRK ELFRRLQKWE LNTYLYAPKD DYKHRMFWRE MYSVEEAEQL MTLISAAREY EIEFIYAISP GLDITFSNPK EVSTLKRKLD QVSQFGCRSF ALLFDDIDHN MCAADKEVFS SFAHAQVSIT NEIYQYLGEP ETFLFCPTEY CGTFCYPNVS QSPYLRTVGE KLLPGIEVLW TGPKVVSKEI PVESIEEVSK IIKRAPVIWD NIHANDYDQK RLFLGPYKGR STELIPRLKG VLTNPNCEFE ANYVAIHTLA TWYKSNMNGV RKDVVMSRQV A (1-350 aa encoded by BC039583)
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
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