Immunogen sequence: NQIDIMQLQA AQTVTQTSAD AIYDCSSLYQ KNYRISGVYK LPPDDFLGSP
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%
Angptl7 (angiopoietin-like 7), alternately known as cornea-derived transcript 6 protein (CDT6) or AngX, is a 346 amino acid secreted protein that is expressed specifically in the stromal layer of cornea. Angptl7 forms disulfide-linked homotetramers via coiled-coil interactions and contains one fibrinogen C-terminal domain. Overexpressed in patients with glaucoma, Angptl7 serves as a potential therapeutic target for glaucoma and has been found to increase collagen expression. The gene encoding Angptl7 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
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Protein Aliases: angiopoietin-like 7; Angiopoietin-like factor; angiopoietin-like factor (CDT6); Angiopoietin-like protein 7; Angiopoietin-related protein 7; Cornea-derived transcript 6 protein
Gene Aliases: ANGPTL7; AngX; CDT6; dJ647M16.1; UNQ313/PRO356
UniProt ID: (Human) O43827
Entrez Gene ID: (Human) 10218
Molecular Function: intercellular signal molecule