Immunogen sequence: PSGSPCTPLLP MAGVLAQNGS ASAPGTVRRL AGRFEGGAEG RAQDADAPEP GLQARADVNG EREAPLTGSG SQENGAPDA
Highest antigen sequence identity to the following orthologs - mouse 61%, rat 64%.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells.
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Protein Aliases: E5; Ephexin-5; Rho GEF 15; Rho guanine nucleotide exchange factor (GEF) 15; Rho guanine nucleotide exchange factor 15; Vsm-RhoGEF
Gene Aliases: ARGEF15; ARHGEF15; E5; Ephexin5; KIAA0915; Vsm-RhoGEF
UniProt ID: (Human) O94989
Entrez Gene ID: (Human) 22899