|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG|
|Immunogen||Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.|
|Storage buffer||PBS, pH 7.2|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Functional Assay (FN)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1:500-1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
MA1-23158 detects ATR in Human samples.
MA1-23158 has been successfully used in Functional assay, Immunoprecipitation, Immunoflourescence, and Western Blot procedures.
MA1-23158 immunogen corresponds to Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR..
Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA.
MA1-23158 was used in ELISA and western blot to investigate the specificity of interleukin 12 antibodies in vitro
|Wilkinson VL,Warrier RR,Truitt TP,Nunes P,Gately MK,Presky DH||Journal of immunological methods (189:15)||1996|