Positive Control: 293T, A431, HeLa, HepG2
Predicted Reactivity: Pig (94%), Chicken (83%), Sheep (94%), Rhesus Monkey (98%), Bovine (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACAC; ACACA; ACACAD; ACC-alpha; ACC1; ACCA; Acetyl CoA Carboxylase 1; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 265; acetyl-CoA carboxylase alpha; Acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Gene Aliases: A530025K05Rik; ACAC; ACACA; ACACAD; ACC; ACC1; ACCA; Gm738
Molecular Function: ligase