|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||A synthetic peptide corresponding to aa 1-24 from the N-terminal of human ACTH|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||0.2-0.4 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 4 publications below|
MA5-13455 targets Adrenocorticotrophic Hormone in IHC (P) applications and shows reactivity with Human samples.
The MA5-13455 immunogen is a synthetic peptide corresponding to aa 1-24 from the N-terminal of human ACTH.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Plurihormonal pituitary adenoma with concomitant adrenocorticotropic hormone (ACTH) and growth hormone (GH) secretion: a report of two cases and review of the literature.
MA5-13455 was used in immunohistochemistry to report on two cases of plurihormonal pituitary adenoma presenting with adrenocorticotropic hormone and growth hormone secretion
|Rasul FT,Jaunmuktane Z,Khan AA,Phadke R,Powell M||Acta neurochirurgica (156:141)||2014|
Incidence, hormonal distribution and postoperative follow up of atypical pituitary adenomas.
MA5-13455 was used in immunohistochemistry to report on the incidence and post-operative follow up of cases of atypical pituitary adenoma
|Yildirim AE,Divanlioglu D,Nacar OA,Dursun E,Sahinoglu M,Unal T,Belen AD||Turkish neurosurgery (23:226)||2013|
Primary adenomyoepithelioma of the sellar region: a case report.
MA5-13455 was used in immunohistochemistry to characterize a specific case of sellar adenomyoepithelioma
|Rychly B,Kazakov DV,Danis D,Szep Z,Michal M||The American journal of surgical pathology (34:1550)||2010|
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging.
MA5-13455 was used in immunohistochemistry to investigate the correlation between aging and cytoplasmic clusterin localization in adenohypophysis
|Ekici AI,Eren B,Türkmen N,Comuno¿lu N,Fedakar R||Endocrine pathology (19:47)||2009|