AGO3 (protein argonaute-3) is required to RNA-mediated gene silencing (RNAi). It binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. AGO3 is proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
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Protein Aliases: argonaute 3; Argonaute RISC catalytic component 3; Argonaute3; eIF-2C 3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 3; hAgo3; Protein argonaute-3
Gene Aliases: AGO3; EIF2C3
UniProt ID: (Human) Q9H9G7
Entrez Gene ID: (Human) 192669
Molecular Function: translation initiation factor