Positive Control: Rat liver tissue, human liver tissue, mouse liver tissue, HepG2.
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence.
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Protein Aliases: ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; Alcohol dehydrogenase 1A; Alcohol dehydrogenase subunit alpha; aldehyde reductase
Gene Aliases: ADH1; ADH1A
UniProt ID: (Human) P07327
Entrez Gene ID: (Human) 124