Immunogen sequence: MAMVSEFLK QAWFIENEEQ EYVQTVKSSK GGPGSAVSPY PTFNPSSDVA ALHKAIMVKG VDEATIIDIL TKRNNAQRQQ IKAAYLQETG KPLDETLKKA LTGHLEEVVL ALLKTPAQFD ADELRAAMKG LGTDEDTLIE ILASRTNKEI RDINRVYREE LKRDLAKDIT SDTSGDFRNA LLSLAKGDRS EDFGVNEDLA DSDARALYEA GERRKGTDVN VFNTILTTRS YPQLRRVFQK YTKYSKHDMN KVLDLELKGD IEKCLTAIVK CATSKPAFFA EKLHQAMKGV GTRHKALIRI MVSRSEIDMN DIKAFYQKMY GISLCQAILD ETKGDYEKIL VALCGGN (1-346 aa encoded by BC001275)
Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANAX1; Annexin A1; Annexin Ac2-26; Annexin I; annexin I (lipocortin I); Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; lipocortin 1; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1
Gene Aliases: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1
Molecular Function: calcium-binding protein