This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
PA1-26351 detects Aurora A from human samples.
PA1-26351 has been successfully used in immunoprecipitation procedures.
The PA1-26351 immunogen is a synthetic peptide, conjugated to KLH, corresponding to a portion of human Serine/Threonine Kinase 15 encoded within exon 5.
Aurora A is a 46 kDa protein that plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Multiple transcript variants encoding the same protein have been found for this gene. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AIK; ARK-1; ARK1; AURA; Aurora 2; Aurora kinase A; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; BTAK; MGC34538; protein phosphatase 1, regulatory subunit 47; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK6; STK7
Gene Aliases: AIK; AIRK1; ARK1; AURA; AURKA; AYK1; BTAK; IAK1; PPP1R47; STK15; STK6; STK7
UniProt ID: (Human) O14965
Entrez Gene ID: (Human) 6790