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PA1-25967 detects Bcl xL from human samples.
PA1-25967 has been successfully used in Western blot procedures. The predicted molecular weight is 28 kDa.
The PA1-25967 immunogen is a synthetic peptide corresponding to residues 20-150 of human Bcl xL.
Store at 4ºC short term. For long term storage, store at -20ºC, avoiding freeze/thaw cycles.
BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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