Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3-hydroxybutyrate dehydrogenase type 2; dehydrogenase/reductase (SDR family) member 6; Dehydrogenase/reductase SDR family member 6; FLJ13261; Oxidoreductase UCPA; R-beta-hydroxybutyrate dehydrogenase; Short chain dehydrogenase/reductase family 15C member 1; short chain dehydrogenase/reductase family 15C, member 1
Gene Aliases: BDH2; DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR; UNQ6308; UNQ6308/PRO20933
UniProt ID: (Human) Q9BUT1
Entrez Gene ID: (Human) 56898
Molecular Function: dehydrogenase