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Invitrogen
MA5-15826 targets BMPR2 in IHC and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15826 immunogen is purified recombinant fragment of human BMPR2 expressed in E. Coli.
MA5-15826 detects BMPR2 which has a predicted molecular weight of approximately 115kDa.
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK
UniProt ID: (Human) Q13873, (Mouse) O35607
Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168
Molecular Function:
TGF-beta receptor
cytokine receptor
kinase
protein kinase
protein kinase receptor
receptor
serine/threonine protein kinase receptor
transferase
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