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Invitrogen
BMPR2 Monoclonal Antibody (1F12)
Product Details
MA5-15826
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F12
Immunogen
Purified recombinant fragment of human BMPR2 expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11153401
Product Specific Information
MA5-15826 targets BMPR2 in indirect ELISA, IHC and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15826 immunogen is purified recombinant fragment of human BMPR2 expressed in E. Coli.
MA5-15826 detects BMPR2 which has a predicted molecular weight of approximately 115kDa.
Target Information
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK
UniProt ID: (Human) Q13873, (Mouse) O35607
Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168
Molecular Function:
serine/threonine protein kinase receptor
mesoderm formation
maternal placenta development
endothelial cell proliferation
positive regulation of endothelial cell proliferation
lymphangiogenesis
blood vessel remodeling
chondrocyte development
negative regulation of systemic arterial blood pressure
transcription from RNA polymerase II promoter
transmembrane receptor protein serine/threonine kinase signaling pathway
brain development
cellular response to starvation
anterior/posterior pattern specification
positive regulation of endothelial cell migration
positive regulation of epithelial cell migration
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of lung blood pressure
signal transduction by protein phosphorylation
proteoglycan biosynthetic process
negative regulation of cell growth
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of BMP signaling pathway
activin receptor signaling pathway
regulation of cell proliferation
positive regulation of osteoblast differentiation
negative regulation of vasoconstriction
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
lung alveolus development
positive regulation of axon extension involved in axon guidance
limb development
endochondral bone morphogenesis
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
positive regulation of cartilage development
retina vasculature development in camera-type eye
cellular response to BMP stimulus
endothelial cell apoptotic process
negative regulation of chondrocyte proliferation
negative regulation of DNA biosynthetic process
protein phosphorylation
retina development in camera-type eye
positive regulation of protein phosphorylation
phosphorylation
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
activin receptor activity, type II
growth factor binding
BMP binding
metal ion binding
BMP receptor activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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