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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • BMPR2 Antibodies

          Invitrogen

          BMPR2 Monoclonal Antibody (1F12)

          2 Published Figures
          2 References
          View all (17) BMPR2 antibodies
          Datasheet
          Protocols
          Questions & Answers
          Tech Support

          Cite BMPR2 Monoclonal Antibody (1F12)

          Datasheet
          Protocols
          Questions & Answers
          Tech Support
          • Antibody Testing Data (3)
          • Published Figures (2)
          BMPR2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          BMPR2 Antibody (MA5-15826) in WB

          Western blot analysis of BMPR2 using BMPR2 monoclonal antibody (Product # MA5-15826) in HeLa (1), A431 (2), NIH/3T3 (3), COS-7 (4) and PC-12 (5) cell lysate. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          MA5-15826

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (IHC)

          1:200-1:1,000
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication

          ELISA (ELISA)

          1:10,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Non-human primate, Rat

          Published species

          Not Applicable

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          1F12

          Immunogen

          Purified recombinant fragment of human BMPR2 expressed in E. Coli.

          Conjugate

          Unconjugated

          Form

          Liquid

          Concentration

          Conc. Not Determined

          Storage buffer

          ascites

          Contains

          0.03% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          RRID

          AB_11153401

          Product Specific Information

          MA5-15826 targets BMPR2 in indirect ELISA, IHC and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.

          The MA5-15826 immunogen is purified recombinant fragment of human BMPR2 expressed in E. Coli.

          MA5-15826 detects BMPR2 which has a predicted molecular weight of approximately 115kDa.

          Target Information

          BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

          View more View less

          Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK

          View more View less

          UniProt ID: (Human) Q13873, (Mouse) O35607

          View more View less

          Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168

          View more View less

          Molecular Function: serine/threonine protein kinase receptor

          Function(s)
          mesoderm formation maternal placenta development endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway brain development cellular response to starvation anterior/posterior pattern specification positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation regulation of lung blood pressure signal transduction by protein phosphorylation proteoglycan biosynthetic process negative regulation of cell growth positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway activin receptor signaling pathway regulation of cell proliferation positive regulation of osteoblast differentiation negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway lung alveolus development positive regulation of axon extension involved in axon guidance limb development endochondral bone morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye cellular response to BMP stimulus endothelial cell apoptotic process negative regulation of chondrocyte proliferation negative regulation of DNA biosynthetic process protein phosphorylation retina development in camera-type eye positive regulation of protein phosphorylation phosphorylation
          Process(es)
          receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding BMP binding metal ion binding BMP receptor activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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