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Invitrogen

BMPR2 Monoclonal Antibody (1F12)

View all (10) BMPR2 antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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Product Details

Tested Applications
Dilution
Immunohistochemistry (IHC)
1/200 - 1/1000
Western Blot (WB)
1/500 - 1/2000
Product Specifications
Species Reactivity
Human, Mouse, Non-human primate, Rat
Host / Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
1F12
Immunogen
Purified recombinant fragment of human BMPR2 expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11153401

Product Specific Information

MA5-15826 targets BMPR2 in IHC and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.

The MA5-15826 immunogen is purified recombinant fragment of human BMPR2 expressed in E. Coli.

MA5-15826 detects BMPR2 which has a predicted molecular weight of approximately 115kDa.

Target Information

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK, BMP type II receptor; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK

UniProt ID: (Human) Q16569, (Mouse) O35607

Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168

Molecular Function: TGF-beta receptor cytokine receptor kinase protein kinase protein kinase receptor receptor serine/threonine protein kinase receptor transferase

Function(s)
mesoderm formation maternal placenta development endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway brain development cellular response to starvation anterior/posterior pattern specification positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation regulation of lung blood pressure signal transduction by protein phosphorylation proteoglycan biosynthetic process negative regulation of cell growth positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway activin receptor signaling pathway regulation of cell proliferation positive regulation of osteoblast differentiation negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway lung alveolus development positive regulation of axon extension involved in axon guidance limb development endochondral bone morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye cellular response to BMP stimulus endothelial cell apoptotic process negative regulation of chondrocyte proliferation negative regulation of DNA biosynthetic process protein phosphorylation retina development in camera-type eye positive regulation of protein phosphorylation phosphorylation
Process(es)
receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding BMP binding metal ion binding BMP receptor activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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