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Invitrogen
Bcl-W Monoclonal Antibody (F.584.7)
Product Details
MA5-15076
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000 | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Not Applicable |
Host/Isotype |
Rabbit / IgG |
Class |
Monoclonal |
Type |
Antibody |
Clone |
F.584.7 |
Immunogen |
Synthetic peptide corresponding to residues surrounding alanine 39 of Bcl-w |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
107 µg/mL |
Purification |
Affinity chromatography |
Storage buffer |
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
Contains |
<0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_10983656 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; c98; protein phosphatase 1, regulatory subunit 51
Gene Aliases: AW048834; BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCL2L2; BCLW; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51
UniProt ID: (Human) Q92843, (Mouse) P70345
Entrez Gene ID: (Human) 599, (Mouse) 12050, (Rat) 60434
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of apoptotic process
Sertoli cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
apoptotic process
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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