Invitrogen

Beclin 1 Polyclonal Antibody

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Beclin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Beclin 1 in paraffin-embedded Human Pancreas tissue. Samples were incubated with polyclonal antibody (Product # PA5-118978) at a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.

Beclin 1 Antibody in Western Blot (WB) — Western blot analysis of Beclin 1 in Lane 1: Porcine Cerebrum lysate; Lane 2: Rat Cerebrum lysate; Lane 3: Mouse Cerebrum lysate; Lane 4: Canine Cerebrum lysate; Lane 5: Bovine Cerebrum lysate; Lane 6: Caprine Cerebrum lysate; Lane 7: T-47D cell lysate. Samples were incubated with polyclonal antibody (Product # PA5-118978) at a dilution of 0.3 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 0.2 µg/mL.

Product Details

PA5-118978

Applications	Tested Dilution	Publications
Western Blot (WB)	0.5-3 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	5-30 µg/mL	-
Immunocytochemistry (ICC/IF)	5-30 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant protein Beclin 1
Conjugate	Unconjugated
Form	Liquid
Concentration	500 µg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS with 50% glycerol
Contains	0.05% Proclin 300
Storage conditions	-20°C

Target Information

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: APG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e

Gene Aliases: ATG6; beclin1; BECN1; GT197; VPS30

UniProt ID: (Human) Q14457

Entrez Gene ID: (Human) 8678

Molecular Function: protease inhibitor