This antibody detects endogenous protein at a molecular weight of 30 and 45 kDa.
Purity is >95% by SDS-PAGE.
C/EBP alpha regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP alpha uses a bipartite structural motif to bind DNA. Two protein chains dimerize through a set of amphipathic alpha helices termed the leucine zipper. Highly basic polypeptide regions emerge from the zipper to form a linked set of DNA contact surfaces. C/EBP alpha appears to function exclusively in terminally-differentiated, growth-arrested cells. Additional family members include C/EBP beta, C/EBP gamma, C/EBP delta and C/EBP epsilon, all of which exhibit similar DNA-binding specificities and affinities to C/EBP alpha. Furthermore, C/EBP beta and C/EBP delta readily form heterodimers both with each other as well as with C/EBP alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C EBP; C/EBP epsilon; C/EBP-related protein 1; C/EBPepsilon; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer binding protein , epsilon; CCAAT/enhancer binding protein epsilon; CCAAT/enhancer-binding protein epsilon
Gene Aliases: C/EBP-epsilon; C/EBPe; C/EPBe; CEBPE; CRP1; Gm294
Molecular Function: basic leucine zipper transcription factor