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Immunogen sequence: QELVGSEGA YKAAVDSFLQ QQHVLGAGGG PGPTQGEEQP PQPPLDPQNL ARPPAPAQTE ALSQLFCSVR TLTAKEELLQ TLRTHLILHM ARAHGYSKVM TGDSCTRLAI KLMTNLALGR GAFLAWDTGF SDERHGDVVV VRPMRDHTLK EVAFYNRLFS VPSVFTPAVD TKAPEKASIH RLMEAFILRL QTQFPSTVST VYRTSEKLVK GPRDGPAAGD SGPRCLLCMC ALDVDAADSA TAFGAQTSSR LSQMQSPIPL TETRTPPGPC CSPGVGWAQR CGQGACRRED PQACIEEQLC YSCRVNMKDL PSLDPLPPYI LAEAQLRTQR AWGLQEIRDC LIEDSDDEAG QS (165-515 aa encoded by BC125269)
Cytoplasmic tRNA 2-thiolation protein 2 (CUT2), also named as C16orf84 or NCS2, is a 515 amino acid protein, which belongs to the CUT2 family. C16orf84 localizes in the cytoplasm and Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). C16orf84 may act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thio-carboxylated URM1 onto the uridine of tRNAs at wobble position.
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Protein Aliases: Cytoplasmic tRNA 2-thiolation protein 2; Cytosolic thiouridylase subunit 2; cytosolic thiouridylase subunit 2 homolog
Gene Aliases: 2310061F22Rik; C16orf84; CTU2; NCS2; UPF0432