Immunogen sequence: LRVSVKAEAP AGPALGLPSP EAESGVDRGE PEPMEVEEGE LEIVPVRRSL KELIPDTSRR YENKAGSFIT GIDVTSKEAI EKKEQRAKRF HFRSEVNLAQ RNVALDRDMM KKAIPKVRLE TIYICGVD
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTD-3195I5.1; CTD-3195I5.5; Nuclear cap-binding protein subunit 3; Protein ELG
Gene Aliases: C17orf85; ELG; HSA277841; NCBP3
UniProt ID: (Human) Q53F19
Entrez Gene ID: (Human) 55421