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Product Details
PA5-23500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acid 460-510 of human Cactin
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2541000
Target Information
Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: functional spliceosome-associated protein c; NY REN 24 antigen; NY-REN-24 antigen; Renal carcinoma antigen NY-REN-24; Splicing factor Cactin
Gene Aliases: C19orf29; C20H19orf29; CACTIN; fSAPc; NY-REN-24
UniProt ID: (Human) Q8WUQ7
Entrez Gene ID: (Pig) 100521180, (Human) 58509, (Dog) 485055
mRNA splicing, via spliceosome
negative regulation of protein phosphorylation
multicellular organism development
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-beta production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
innate immune response
negative regulation of type I interferon-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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