The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
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Protein Aliases: Aspartate carbamoyltransferase; CAD protein; CAD trifunctional protein; Dihydroorotase; Glutamine-dependent carbamoyl-phosphate synthase; multifunctional protein CAD
Gene Aliases: CAD; CDG1Z
UniProt ID: (Human) P27708
Entrez Gene ID: (Human) 790