Invitrogen

CD264 (TRAIL-R4) Recombinant Rabbit Monoclonal Antibody (10Y1N4)

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CD264 (TRAIL-R4) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of CD264 (TRAIL-R4) in human brain using a Recombinant Monoclonal antibody (Product # MA5-42826) at a dilution of 1:100. Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol..

CD264 (TRAIL-R4) Antibody in Western Blot (WB) — Western Blot analysis of CD264 (TRAIL-R4) in various cell lines using a CD264 (TRAIL-R4) Recombinant Monoclonal antibody (Product # MA5-42826) at a dilution of 1:1,000. 25 µg of lysate or protein were loaded into each lane. A blocking buffer of 3% nonfat dry milk in TBST was used. An HRP conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a 1:10,000 dilution. Chemiluminescent detection was performed for 10s.

Product Details

MA5-42826

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500 - 1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50 - 1:200	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Recombinant Monoclonal
Type	Antibody
Clone	10Y1N4
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 287-386 of human DCR2 (Q9UBN6). View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.61 mg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Positive test controls include: Mouse liver, Mouse kidney, Rat liver, Rat kidney.

Target Information

TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. A fourth member of the emerging TRAIL receptor family, TRAIL-R4, has signaling capacity similar to that of TRAIL-R1 and TRAIL-R2 with respect to NF-kappaB activation, but differs in its inability to induce apoptosis. Like TRAIL-R1 and TRAIL-R2, this receptor shows widespread tissue expression. The human TRAIL-R4 gene has been mapped to chromosome 8p22-21, clustered with three other TRAIL receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD264; DcR2; Decoy receptor 2; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; Tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily member 10d, decoy with truncated death domain; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

Gene Aliases: CD264; DCR2; TNFRSF10D; TRAIL-R4; TRAILR4; TRUNDD; UNQ251/PRO288

UniProt ID: (Human) Q9UBN6

Entrez Gene ID: (Human) 8793

Molecular Function: transmembrane signal receptor