|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Human CD3 delta|
|Storage buffer||PBS with BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The R-phycoerythrin (PE)-Texas Red® conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
Analyte Specific Reagent
Genetic and epigenetic variation in the lineage specification of regulatory T cells.
MHCD0317 was used in flow cytometry to study factors that specify the Treg lineage
|Arvey A,van der Veeken J,Plitas G,Rich SS,Concannon P,Rudensky AY||eLife (4:null)||2015|
Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients.
MHCD0317 was used in flow cytometry to identify surrogates of anti-tumor immune responsiveness after DC vaccination.
|Fong B,Jin R,Wang X,Safaee M,Lisiero DN,Yang I,Li G,Liau LM,Prins RM||PloS one (7:null)||2012|
NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.
MHCD0317 was used in flow cytometry to study the molecular mechanisms that regulate the "recall" NK cell response after rabies vaccination
|Horowitz A,Behrens RH,Okell L,Fooks AR,Riley EM||Journal of immunology (Baltimore, Md. : 1950) (185:2808)||2010|
Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis.
MHCD0317 was used in flow cytometry to assess the immune responses of peripheral blood to chlamydial antigens.
|Gall A,Horowitz A,Joof H,Natividad A,Tetteh K,Riley E,Bailey RL,Mabey DC,Holland MJ||Frontiers in microbiology (2:null)||2011|
Peripheral immature CD2-/low T cell development from type 2 to type 1 cytokine production.
MHCD0317 was used in flow cytometry to identify and characterize immature CD2(-/low) T cells in peripheral blood.
|Loza MJ,Perussia B||Journal of immunology (Baltimore, Md. : 1950) (169:3061)||2002|