|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Mouse CTL clone V4 cells|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2-8 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 4 publications below|
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors.
MA1-10219 was used in flow cytometry to investigate factors that mediate induction and maintenance of the 3D configuration of the epithelial network in fetal thymic lobes in vitro.
|Germeraad WT,Kawamoto H,Itoi M,Jiang Y,Amagai T,Katsura Y,van Ewijk W||The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (51:1225)||2003|
Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains.
MA1-10219 was used in flow cytometry to assess the proliferative potential of thymic progenitors that are T cell lineage restricted.
|Kawamoto H,Ohmura K,Fujimoto S,Lu M,Ikawa T,Katsura Y||European journal of immunology (33:606)||2003|
Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome.
MA1-10219 was used in flow cytometry to elucidate role of SOD-1 overexpression in thymocyte biology.
|Paz-Miguel JE,Flores R,Sánchez-Velasco P,Ocejo-Vinyals G,Escribano de Diego J,López de Rego J,Leyva-Cobián F||Journal of immunology (Baltimore, Md. : 1950) (163:5399)||1999|
Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells.
MA1-10219 was used in flow cytometry to report that FcR is a useful marker to isolate the most immature population of murine fetal thymic cells.
|Hattori N,Kawamoto H,Katsura Y||The Journal of experimental medicine (184:1901)||1996|