Product References
Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice.
Aging and disease
Elsayed R,Elashiry M,Liu Y,Morandini AC,El-Awady A,Elashiry MM,Hamrick M,Cutler CW
MA1-146 was used in Flow Cytometry, Immunocytochemistry, Western Blot, In Vivo to conclude that immune senescence, compounded by advanced age, and accelerated by oral dysbiosis and its induced SASP exosomes, plays a pivotal role in the pathophysiology of experimental periodontitis.
Wed Feb 01 00:00:00 EST 2023
Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
PloS one
Zhang ZY,Zhai C,Yang XY,Li HB,Wu LL,Li L
MA1-146 was used in Western Blotting to show that knockdown of CD146 exerts promotional effects on EndMT via activating Wnt/β-catenin pathway and the upregulation of CD146 might play a protective role against EndMT and cardiac fibrosis.
Fri Aug 26 00:00:00 EDT 2022
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Journal of oncology
Zhu Q,Yuan J,He Y,Hu Y
Published figure using CD4 monoclonal antibody (Product # MA1-146) in Immunohistochemistry
Wed Apr 27 00:00:00 EDT 2022
Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma.
World journal of gastrointestinal oncology
Deng Z,Teng YJ,Zhou Q,Ouyang ZG,Hu YX,Long HP,Hu MJ,Mei S,Lin FX,Dai XJ,Zhang BY,Feng T,Tian XF
MA1-146 was used in Western Blotting to investigate the efficacy of shuyu pills for hepatocellular carcinoma treatment via simultaneous HIF-1α and PD-L1 inhibition and the mechanism involved.
Mon Nov 15 00:00:00 EST 2021
Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma.
World journal of gastrointestinal oncology
Deng Z,Teng YJ,Zhou Q,Ouyang ZG,Hu YX,Long HP,Hu MJ,Mei S,Lin FX,Dai XJ,Zhang BY,Feng T,Tian XF
MA1-146 was used in Western Blotting to investigate the efficacy of shuyu pills for hepatocellular carcinoma treatment via simultaneous HIF-1α and PD-L1 inhibition and the mechanism involved.
Mon Nov 15 00:00:00 EST 2021
Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.
Scientific reports
Baloche V,Rivière J,Tran TBT,Gelin A,Bawa O,Signolle N,Diop MBK,Dessen P,Beq S,David M,Busson P
Published figure using CD4 monoclonal antibody (Product # MA1-146) in Immunohistochemistry
Thu Mar 04 00:00:00 EST 2021
Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy.
Journal for immunotherapy of cancer
Liu HY,Pedros C,Kong KF,Canonigo-Balancio AJ,Xue W,Altman A
MA1-146 was used in Immunohistochemistry to demonstrate the potential utility of PKCη inhibition as a viable clinical approach to treat patients with cancer, especially when combined with adjuvant therapies.
Wed Sep 01 00:00:00 EDT 2021
Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy.
Journal for immunotherapy of cancer
Liu HY,Pedros C,Kong KF,Canonigo-Balancio AJ,Xue W,Altman A
MA1-146 was used in Immunohistochemistry to demonstrate the potential utility of PKCη inhibition as a viable clinical approach to treat patients with cancer, especially when combined with adjuvant therapies.
Wed Sep 01 00:00:00 EDT 2021
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity.
Cell
Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S
MA1-146 was used in Immunohistochemistry (Paraffin) to demonstrate a critical role of the B cell subset switch in chemotherapy response, which has implications in designing novel anti-cancer therapies.
Thu Mar 19 00:00:00 EDT 2020
A direct link between MITF, innate immunity, and hair graying.
PLoS biology
Harris ML,Fufa TD,Palmer JW,Joshi SS,Larson DM,Incao A,Gildea DE,Trivedi NS,Lee AN,Day CP,Michael HT,Hornyak TJ,Merlino G,Pavan WJ
MA1-146 was used in Immunohistochemistry to show melanogenesis associated transcription factor MITF can regulate systemic innate immune gene expression, the dysregulation of which can lead to hair depigmenting indicating a role in vitiligo.
Tue May 01 00:00:00 EDT 2018
The role of immune cell subpopulations in the growth and rejection of TC-1/A9 tumors in novel mouse strains differing in the H2-D haplotype and NKC domain.
Oncology letters
Indrová M,Rossowska J,Pajtasz-Piasecka E,Mikyšková R,Richter J,Rosina J,Sedlacek R,Fišerová A
MA1-146 was used in Flow Cytometry to elucidate the role of cluster of differentiation8+, CD4+, natural killer, and myeloid cells in the course of the growth and rejection of experimental major histocompatibility complex class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice.
Thu Mar 01 00:00:00 EST 2018
A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Oh DS,Jung HE,Lee HK
MA1146 was used in flow cytometry to propose that type 2 immunity is induced by a unique mechanism in the genital tract
Tue Feb 14 00:00:00 EST 2017
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
MA1146 was used in flow cytometry to characterize conventional and regulatory T cells during pregnancy
Tue Jan 10 00:00:00 EST 2017
A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice.
Haematologica
Cañete A,Carmona R,Ariza L,Sánchez MJ,Rojas A,Muñoz-Chápuli R
MA1146 was used in flow cytometry to utilize a G2-Gata4Cre;R26REYFP mouse line to track the developmental fate of the G2-Gata4 cell lineage
Sat Apr 01 00:00:00 EDT 2017
Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice.
Cellular and molecular life sciences : CMLS
van Nieuwenhuijze A,Dooley J,Humblet-Baron S,Sreenivasan J,Koenders M,Schlenner SM,Linterman M,Liston A
MA1146 was used in flow cytometry to evaluate miR-29a in B cells as a potential therapeutic target in arthritis
Thu Jun 01 00:00:00 EDT 2017
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Journal of immunology (Baltimore, Md. : 1950)
Marshall NB,Vong AM,Devarajan P,Brauner MD,Kuang Y,Nayar R,Schutten EA,Castonguay CH,Berg LJ,Nutt SL,Swain SL
MA1146 was used in flow cytometry to determine that NKG2C/E identifies the CD4 T cell effector subset ThCTL that develop in the lung during influenza A virus infection in mice
Wed Feb 01 00:00:00 EST 2017
CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.
Nature communications
Barthels C,Ogrinc A,Steyer V,Meier S,Simon F,Wimmer M,Blutke A,Straub T,Zimber-Strobl U,Lutgens E,Marconi P,Ohnmacht C,Garzetti D,Stecher B,Brocker T
MA1146 was used in flow cytometry to report a CD40-dependent mechanism capable of abrogating inducible T regulatory cell induction by dendritic cells
Thu Mar 09 00:00:00 EST 2017
Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells.
Scientific reports
Chien CH,Yu HC,Chen SY,Chiang BL
MA1146 was used in flow cytometry to generate and characterize Treg-of-B cells
Wed Apr 12 00:00:00 EDT 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
MA1146 was used in flow cytometry to assess the role of p38 signaling in limiting regulatory T cell induction
Fri Feb 03 00:00:00 EST 2017
Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.
The Journal of clinical investigation
Marichal T,Gaudenzio N,El Abbas S,Sibilano R,Zurek O,Starkl P,Reber LL,Pirottin D,Kim J,Chambon P,Roers A,Antoine N,Kawakami Y,Kawakami T,Bureau F,Tam SY,Tsai M,Galli SJ
MA1146 was used in flow cytometry to show that deletion of the gene encoding RAB guanine nucleotide exchange factor 1 in keratinocytes severely impairs epidermal barrier function in mice
Thu Dec 01 00:00:00 EST 2016
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
European journal of immunology
Fröhlich M,Gogishvili T,Langenhorst D,Lühder F,Hünig T
MA1-146 was used in Immunodepletion to examine the role of CD28-mediated costimulation in secondary CD8(+) T-cell responses.
Fri Jul 01 00:00:00 EDT 2016
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Poczobutt JM,Nguyen TT,Hanson D,Li H,Sippel TR,Weiser-Evans MC,Gijon M,Murphy RC,Nemenoff RA
MA1-146 was used in Flow Cytometry to reveal an antitumorigenic role for 5-LO products in the microenvironment during lung cancer progression through T cell regulation.
Fri Jan 15 00:00:00 EST 2016
Glibenclamide Prevents Diabetes in NOD Mice.
PloS one
Lamprianou S,Gysemans C,Bou Saab J,Pontes H,Mathieu C,Meda P
MA1146 was used in flow cytometry to explore if the anti-diabetic sulphonylurea glibenclamide protects insulin-producing cells against conditions mimicking those expected at the onset of type 1 diabetes
Tue Jul 18 00:00:00 EDT 2017
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Journal of immunology (Baltimore, Md. : 1950)
Sun C,Schattgen SA,Pisitkun P,Jorgensen JP,Hilterbrand AT,Wang LJ,West JA,Hansen K,Horan KA,Jakobsen MR,O'Hare P,Adler H,Sun R,Ploegh HL,Damania B,Upton JW,Fitzgerald KA,Paludan SR
MA1-146 was used in Flow Cytometry to report that murine gammaherpesvirus 68 induces very limited innate immune responses through DNA-stimulated pathways.
Sun Feb 15 00:00:00 EST 2015
Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation.
Neuroscience
Yang W,Vethanayagam RR,Dong Y,Cai Q,Hu BH
Published figure using CD4 monoclonal antibody (Product # MA1-146) in Immunofluorescence
Thu Sep 10 00:00:00 EDT 2015
Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis.
PloS one
Stachtea XN,Tykesson E,van Kuppevelt TH,Feinstein R,Malmström A,Reijmers RM,Maccarana M
MA1-146 was used in flow cytometry and immunohistochemistry - paraffin section to study the display of embryological defects and neonatal lethality despite normal lymphoid and non-lymphoid organogenesis
Wed Jun 15 00:00:00 EDT 2016
Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice.
PloS one
Griffiths KL,Stylianou E,Poyntz HC,Betts GJ,Fletcher HA,McShane H
MA1-146 was used in flow cytometry to determine optimal IL-17-inducing conditions using a vaccine and Mycobacterium tuberculosis challenge strategy
Tue Feb 24 00:00:00 EST 2015
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Blood
Ahonen CL,Wasiuk A,Fuse S,Turk MJ,Ernstoff MS,Suriawinata AA,Gorham JD,Kedl RM,Usherwood EJ,Noelle RJ
MA1-146 was used in Immunocytochemistry to report the therapeutic effects of combinatorial use of CD40 and TLR agonists as a cancer vaccine.
Sat Mar 15 00:00:00 EDT 2008
Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Barron L,Knoechel B,Lohr J,Abbas AK
MA1-146 was used in flow cytometry to define the contributions of apoptosis and anergy to the maintenance of self-tolerance to a systemic antigen
Sat Mar 01 00:00:00 EST 2008
The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRbeta chains than fetal progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Lu M,Tayu R,Ikawa T,Masuda K,Matsumoto I,Mugishima H,Kawamoto H,Katsura Y
MA1-146 was used in flow cytometry to study T cell progenitors in the adult thymus
Tue Nov 01 00:00:00 EST 2005
Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.
Proceedings of the National Academy of Sciences of the United States of America
Belz GT,Smith CM,Kleinert L,Reading P,Brooks A,Shortman K,Carbone FR,Heath WR
MA1-146 was used in Immunopurification to examine the distinct migrating and nonmigrating dendritic cell populations involved in MHC class I-restricted antigen presentation after lung infection with virus.
Tue Jun 08 00:00:00 EDT 2004
The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection.
The Journal of experimental medicine
Xu H,Wipasa J,Yan H,Zeng M,Makobongo MO,Finkelman FD,Kelso A,Good MF
MA1-146 was used in flow cytometry to study CD4 T cell populations during and after malaria infection.
Mon Apr 01 00:00:00 EST 2002
An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3.
The Journal of experimental medicine
Farrar JD,Ouyang W,Löhning M,Assenmacher M,Radbruch A,Kanagawa O,Murphy KM
MA1-146 was used in flow cytometry to study the role of IL-12 and IL-4 in Th1/Th2 differentiation.
Mon Mar 05 00:00:00 EST 2001
B7 blockade prevents activation-induced cell death of thymocytes.
International immunology
Samoilova EB,Horton JL,Bassiri H,Zhang H,Linsley PS,Carding SR,Chen Y
MA1-146 was used in flow cytometry to elucidate the role of B7 in thymic selection.
Sat Nov 01 00:00:00 EST 1997
Growth hormone stimulates the proliferation of activated mouse T lymphocytes.
Endocrinology
Postel-Vinay MC,de Mello Coelho V,Gagnerault MC,Dardenne M
MA1-146 was used in flow cytometry to report that bGH stimulates the proliferation of activated murine T cells.
Thu May 01 00:00:00 EDT 1997
CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
Nature
Wu L,Scollay R,Egerton M,Pearse M,Spangrude GJ,Shortman K
MA1-146 was used in flow cytometry to study precursors of thymic T cells
Thu Jan 03 00:00:00 EST 1991