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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||(C57 BL/6 x DBA/2)F1 mouse bone marrow derived stromal cells clone BM52.|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2 µg/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD44 antigen, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, PGP-I, extracellular matrix receptor III, hermes antigen, hyaluronate receptor, lymphocyte antigen 24, phagocytic glycoprotein 1, phagocytic glycoprotein I, Cell surface glycoprotein CD44, hyaluronate binding protein, GP90 lymphocyte homing adhesion receptor, PGP-1
AW121933, AW146109, Ly-24, AU023126, HERMES, Pgp-1
Signal transduction Intracellular signaling cascade MAPKKK cascade Cell communication Cell adhesion-mediated signaling Immunity and defense Oncogenesis Other oncogenesis Apoptosis Inhibition of apoptosis Cell structure and motility Cell motility Cell adhesion