|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Leucocytes from a patient suffering from a LGL type leukaemia.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||20ul x 100ul whole blood or 10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody reacts with both cell surface-expressed and soluble form of CD44 antigen. It is negative on platelets and hepatocytes.
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche.
MA1-19568 was used in flow cytometry to assess the human hematopoietic stem cell self-renewal potential and quiescence in an in vitro leukemic niche without leukemic cells
|Vanegas NP,Vernot JP||Experimental hematology and oncology (6:null)||2017|
|Not Applicable||Not Cited||
Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment.
MA1-19568 was used in flow cytometry to use flow cytometry to characterize mesenchymal stromal cell subsets and abnormalities
|Campioni D,Moretti S,Ferrari L,Punturieri M,Castoldi GL,Lanza F||Haematologica (91:364)||2006|
Susceptibility of human placenta derived mesenchymal stromal/stem cells to human herpesviruses infection.
MA1-19568 was used in flow cytometry to assess the susceptibility of fetal membranes-derived mesenchymal stromal/stem cells to all members of the human Herpesviridae family.
|Avanzi S,Leoni V,Rotola A,Alviano F,Solimando L,Lanzoni G,Bonsi L,Di Luca D,Marchionni C,Alvisi G,Ripalti A||PloS one (8:null)||2013|