|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant protein corresponding to the external domain of the CD5 molecule|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:2|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20-1:40|
|Western Blot (WB)||1:10-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-13308 targets CD5 in IHC (P), FACS and WB applications and shows reactivity with Human samples.
The MA5-13308 immunogen is recombinant protein corresponding to the external domain of the CD5 molecule.
The CD5, a transmembrane protein, is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center cell lymphoma are CD5-.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status and p53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type.
MA5-13308 was used in immunohistochemistry to study the potential association of a range of factors with nasal type cutaneous extranodal natural killer/T-cell lymphoma
|Wang TT,Xu C,Liu SL,Kan B,Ran YP,Liu WP,Li GD,Wang L||Chinese medical journal (126:1281)||2013|
Primary follicular lymphoma of the epididymis positive for t(14;18)(q32;q21)/IGH-BCL2 and negative for BCL2 protein expression: a case report.
MA5-13308 was used in immunohistochemistry to report on a case of primary follicular lymphoma of the epididymis
|Tralongo V,Becchina G,Nagar C,Ottoveggio G,Mason S,Seno B,Sessa F,Frattini M,Genovese F||Journal of medical case reports (6:null)||2012|
Anaplastic large cell lymphoma with paraneoplastic leukocytosis: a clinicopathological analysis of five cases.
MA5-13308 was used in immunohistochemistry to report on five cases of anaplastic large cell lymphoma with paraneoplastic leukocytosis
|Chang IW,Chen HK,Ma MC,Huang WT||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (119:794)||2011|
Composite biclonal marginal zone lymphoma of lung and chronic lymphocytic leukemia: pathologic, phenotypic, cytogenetic, and molecular study.
MA5-13308 was used in immunohistochemistry to investigate the coexistence of mucosa-associated lymphoid tissue lymphoma and chronic lymphocytic leukemia in a patient
|Bhagavathi S,Micale MA,Douglas-Nikitin V,Ballouz S,Neumann K,Blenc AM||International journal of surgical pathology (19:377)||2011|
Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features.
MA5-13308 was used in immunohistochemistry to study the clinical and genetic characteristics of chronic lymphocytic leukemia with t(14;19)(q32;q13)
|Huh YO,Schweighofer CD,Ketterling RP,Knudson RA,Vega F,Kim JE,Luthra R,Keating MJ,Medeiros LJ,Abruzzo LV||American journal of clinical pathology (135:686)||2011|
Tumour eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma.
MA5-13308 was used in immunohistochemistry to investigate an immunohistochemistry method to distinguish type B3 thymoma from thymic carcinoma
|Khoury T,Chandrasekhar R,Wilding G,Tan D,Cheney RT||International journal of experimental pathology (92:87)||2011|
Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue involving different sites.
MA5-13308 was used in immunohistochemistry to study the pathogenesis of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue
|Konoplev S,Lin P,Qiu X,Medeiros LJ,Yin CC||American journal of clinical pathology (134:112)||2010|
Immunohistochemical profile and fluorescence in situ hybridization analysis of diffuse large B-cell lymphoma in northern China.
MA5-13308 was used in immunohistochemistry to investigate the expresson of multiple genes in diffuse large B-cell lymphoma in northern China
|Li T,Medeiros LJ,Lin P,Yin H,Littlejohn M,Im W,Lennon PA,Hu P,Jorgensen JL,Liang M,Guo H,Yin CC||Archives of pathology and laboratory medicine (134:759)||2010|
Intravascular lymphocytosis in acute appendicitis: potential mimicry of chronic lymphocytic leukaemia.
MA5-13308 was used in immunohistochemistry to compare intravascular lymphocytosis in appendectomy specimens with intravascular lymphoid neoplasia
|Lee S,Ogilvie RT,Dupre M,Gao ZH||Histopathology (55:660)||2009|
MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis.
MA5-13308 was used in immunohistochemistry to study MYC translocation and poor prognosis in chronic lymphocytic leukaemia
|Huh YO,Lin KI,Vega F,Schlette E,Yin CC,Keating MJ,Luthra R,Medeiros LJ,Abruzzo LV||British journal of haematology (142:36)||2008|
ZAP70 expression assessed by immunohistochemistry on peripheral blood: a simple prognostic assay for patients with chronic lymphocytic leukemia.
MA5-13308 was used in immunohistochemistry to investigate ZAP70 expression in peripheral blood specimens using an immunohistochemical assay and its prognostic significance for chronic lymphocytic leukemia
|Roullet M,Sargent R,Pasha T,Cajiao I,Elstrom R,Smith T,Liebhaber S,Zhang P,Bagg A||Applied immunohistochemistry and molecular morphology : AIMM (15:471)||2007|
Lymph node involvement by Langerhans cell histiocytosis: a clinicopathologic and immunohistochemical study of 20 cases.
MA5-13308 was used in immunohistochemistry to investigate the Langerhans cell histiocytosis in lymph nodes
|Edelweiss M,Medeiros LJ,Suster S,Moran CA||Human pathology (38:1463)||2007|
Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.
MA5-13308 was used in immunohistochemistry to investigate the role of Noxa expression in the pathogenesis of chronic lymphocytic leukemia
|Smit LA,Hallaert DY,Spijker R,de Goeij B,Jaspers A,Kater AP,van Oers MH,van Noesel CJ,Eldering E||Blood (109:1660)||2007|
Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma.
MA5-13308 was used in immunohistochemistry to investigate the clinical, morphologic and immunophenotypic features of typical and blastoid mantle cell lymphoma in five patients
|Yin CC,Medeiros LJ,Cromwell CC,Mehta AP,Lin P,Luthra R,Abruzzo LV||Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (20:1)||2007|
Lymphomas involving the pleura: a clinicopathologic study of 34 cases diagnosed by pleural biopsy.
MA5-13308 was used in immunohistochemistry to report the clinicopathologic features of pleural lymphomas
|Vega F,Padula A,Valbuena JR,Stancu M,Jones D,Medeiros LJ||Archives of pathology and laboratory medicine (130:1497)||2006|
Diagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL).
MA5-13308 was used in immunohistochemistry to study parameters for the diagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma
|Asaad NY,Abd El-Wahed MM,Dawoud MM||Journal of the Egyptian National Cancer Institute (17:279)||2005|
EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient.
MA5-13308 was used in immunohistochemistry to investigate the Epstein-Barr virus-associated lymphoproliferative disorders after kidney transplant
|Yin CC,Medeiros LJ,Abruzzo LV,Jones D,Farhood AI,Thomazy VA||American journal of clinical pathology (123:222)||2005|
Inflammatory pseudotumor of the spleen with EBV positivity: report of a case.
MA5-13308 was used in immunohistochemistry to report on a case of inflammatory pseudotumor of the spleen involving EBV infection
|Oz Puyan F,Bilgi S,Unlu E,Yalcin O,Altaner S,Demir M,Cakir B||European journal of haematology (72:285)||2004|
Waldenstrom macroglobulinemia involving extramedullary sites: morphologic and immunophenotypic findings in 44 patients.
MA5-13308 was used in immunohistochemistry to conduct morphologic and immunophenotypic characterisation of Waldenstrom macroglobulinemia in patients
|Lin P,Bueso-Ramos C,Wilson CS,Mansoor A,Medeiros LJ||The American journal of surgical pathology (27:1104)||2003|
Epstein-Barr virus-associated lymphoproliferative disease occurring in a patient with sarcoidosis treated by methotrexate and methylprednisolone.
MA5-13308 was used in immunohistochemistry to report on a case of EBV-associated lymphoproliferative disease in a sarcoidosis patient treated with methotrexate and methylprednisolone
|Theate I,Michaux L,Dardenne S,Guiot Y,Brière J,Emile FJ,Fabiani B,Detry R,Gaulard P||European journal of haematology (69:248)||2002|
Epstein-Barr virus-positive B-cell lymphoproliferative disorders arising in immunodeficient patients previously treated with fludarabine for low-grade B-cell neoplasms.
MA5-13308 was used in immunohistochemistry to investigate the Epstein-Barr virus-positive B-cell lymphoproliferative disorders in immunodeficient patients
|Abruzzo LV,Rosales CM,Medeiros LJ,Vega F,Luthra R,Manning JT,Keating MJ,Jones D||The American journal of surgical pathology (26:630)||2002|
|Not Applicable||Not Cited||
R-CHOP regimen can significantly decrease the risk of disease relapse and progression in patients with non-germinal center B-cell subtype diffuse large B-cell lymphoma.
MA5-13308 was used in immunohistochemistry - paraffin section to determine the role of rituximab and a CHOP-like regimen in the treatment of non-germinal center B-cell subtype diffuse large B-cell lymphoma
|He XH,Li B,Yang S,Lu N,Zhang X,Zou SM,Li YX,Song YW,Zheng S,Dong M,Zhou SY,Yang JL,Liu P,Zhang CG,Qin Y,Feng FY,Shi YK||Chinese journal of cancer (31:306)||2012|