DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons.
Journal of neurochemistry
Mazza MC,Shuck SC,Lin J,Moxley MA,Termini J,Cookson MR,Wilson MA
A15409 was used in flow cytometry experiments to suggest that DJ-1 is not a deglycase and has only a minor role in protecting neurons against methylglyoxal toxicity.
Mon Aug 01 00:00:00 EDT 2022
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
A15409 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With Leishmania major.
Frontiers in immunology
Kauffmann F,Meert E,de Jonge K,Elkrim Y,Hanot Mambres D,Denis O,Muraille E,Magez S,De Trez C
A15409 was used in Flow cytometry/Cell sorting to refine the role of IL-12p40 cytokine.
Fri May 10 00:00:00 EDT 2019
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.
Journal of immunology (Baltimore, Md. : 1950)
Cecchinato V,Bernasconi E,Speck RF,Proietti M,Sauermann U,D'Agostino G,Danelon G,Rezzonico Jost T,Grassi F,Raeli L,Schöni-Affolter F,Stahl-Hennig C,Uguccioni M
A15409 was used in flow cytometry to suggest that persistent immune activation causes impairment of lymphocytes to respond to chemotactic stimuli, preventing their trafficking from the blood stream to peripheral organs
Sun Jan 01 00:00:00 EST 2017
Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human.
International journal of cancer
Andzinski L,Kasnitz N,Stahnke S,Wu CF,Gereke M,von Köckritz-Blickwede M,Schilling B,Brandau S,Weiss S,Jablonska J
A15409 was used in flow cytometry to study the effects of IFN signaling on neutrophil polarization
Fri Apr 15 00:00:00 EDT 2016
Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.
Synapse (New York, N.Y.)
Sandiego CM,Nabulsi N,Lin SF,Labaree D,Najafzadeh S,Huang Y,Cosgrove K,Carson RE
A15409 was used in flow cytometry to investigate the findings of a recent pilot study in baboons which reported a significant global decrease from baseline [C]ABP688 binding after increasing endogenous glutamate with 50 mg/kg N-acetylcysteine (NAC), with no change from test to retest.
Thu Aug 01 00:00:00 EDT 2013