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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • CD7 Antibodies

          Invitrogen

          CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), FITC, eBioscience™

          1 Published Figure
          1 Reference
          View all (109) CD7 antibodies
          Datasheet
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          Datasheet
          Protocols
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          Cite CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), FITC, eBioscience™

          • Antibody Testing Data (1)
          • Published Figures (1)
          CD7 Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.
          CD7 Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          CD7 Antibody (11-0079-42) in Flow

          Staining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (left) or Anti-Human CD7 FITC (right). Cells in the lymphocyte gate were used for analysis. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          CD7 Antibody in Flow Cytometry (Flow)
          CD7 Antibody in Flow Cytometry (Flow)

          Product Details

          11-0079-42

          Applications
          Tested Dilution
          Publications

          Flow Cytometry (Flow)

          5 µL (0.25 µg)/test
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human

          Published species

          Not Applicable

          Host/Isotype

          Mouse / IgG1, kappa

          Recommended Isotype Control

          Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™

          Class

          Monoclonal

          Type

          Antibody

          Clone

          eBio124-1D1 (124-1D1)

          Conjugate

          FITC FITC FITC
          • Unconjugated
          • Alexa Fluor 532 
          • Alexa Fluor 700 
          • APC 
          • APC-eFluor 780
          • Biotin 
          • Brilliant UV 737
          • Brilliant Violet 650
          • eFluor 450
          • NovaFluor Blue 660-120S
          • NovaFluor Blue 690
          • NovaFluor Red 700
          • NovaFluor Red 725
          • NovaFluor Red 755
          • NovaFluor Yellow 610
          • NovaFluor Yellow 700
          • PE 
          • PE-Cyanine5.5
          • PE-Cyanine7
          • Super Bright 436
          • Super Bright 600
          • Super Bright 702
          • Request custom conjugation

          Excitation/Emission Max

          498/517 nm View spectra spectra

          Form

          Liquid

          Concentration

          5 µL/Test

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.2, with BSA

          Contains

          0.09% sodium azide

          Storage conditions

          4°C, store in dark, DO NOT FREEZE!

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2572434

          Product Specific Information

          Description: The eBio124-1D1 monoclonal antibody reacts with human CD7, also known as gp40 and Leu9. CD7, a 40 kD receptor, is a member of the immunoglobulin gene superfamily. The N-terminal amino acid sequence (aa1-107) is highly homologous to Ig kappa light chain sequence; while the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T lymphocytes, and T cell leukemias. It is also found on natural killer cells, a small suppopulation of normal B cells and on maligant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity, as measured by calcium flux, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

          A clonogenic subpopulation of human CD34(+) CD38(-) cord blood cells that express CD45RA and HLA-DR and high levels of the CD7 has been reported. These cells possess the capacity for lymphopoiesis. They can generate B-cells, natural killer cells, and dendritic cells but do not possess the capacity to develop into myeloid cells or erythroid cells. The CD7(+) phenotype distinguishes primitive human lymphoid progenitors from pluripotent stem cells.

          Furthermore, it has been suggested that CD7 co-operates with CD28 during Treg function, as mice deficient in both CD28 and CD7 have reduced total numbers of Tregs and these Tregs have reduced suppressive activity.

          Applications Reported: This eBio124-1D1 (124-1D1) antibody has been reported for use in flow cytometric analysis.

          Applications Tested: This eBio124-1D1 (124-1D1) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

          Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

          Filtration: 0.2 µm post-manufacturing filtered.

          Target Information

          CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          How to use the Panel Builder

          Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

          Bioinformatics

          Protein Aliases: CD7; CD7 antigen (p41); GP40; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41

          View more View less

          Gene Aliases: CD7; GP40; LEU-9; Tp40; TP41

          View more View less

          UniProt ID: (Human) P09564

          View more View less

          Entrez Gene ID: (Human) 924

          View more View less

          Function(s)
          receptor activity
          Process(es)
          adaptive immune response immune response transmembrane receptor protein tyrosine kinase signaling pathway T cell activation homeostasis of number of cells within a tissue
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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