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CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72.
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Protein Aliases: B-cell differentiation antigen CD72; CD72; Ly-32; Lyb-2; Lymphocyte antigen 32
Gene Aliases: Cd72; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2
UniProt ID: (Mouse) P21855
Entrez Gene ID: (Mouse) 12517
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