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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Synthetic peptide derived from CD8 alpha chain sequence.|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||1/20 - 1/40|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 3 publications below|
Heat-mediated antigen retrieval using Tris/EDTA (pH 8) is recommended for the staining of paraffin sections. A suggested positive control for this product is human tonsil
CD8 is expressed on T-cells and exists either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. CD8 functions as a co-receptor with the T-cell receptor and mediates efficient cel-to-cell interactions within the immune system. The CD8 alpha chain specifically binds to class I MHC molecules. CD8 alpha is expressed by a subset of T lymphocytes, most thymocytes, and the majority of NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.
MA1-80231 was used in immunohistochemistry to compare the prognostic value of immune criteria versus the AJCC/UICC-TNM staging system in colorectal cancer
|Mlecnik B,Tosolini M,Kirilovsky A,Berger A,Bindea G,Meatchi T,Bruneval P,Trajanoski Z,Fridman WH,Pagès F,Galon J||Journal of clinical oncology : official journal of the American Society of Clinical Oncology (29:610)||2011|
Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer.
MA1-80231 was used in immunohistochemistry to use biomolecular network reconstruction to investigate the immune responses in colorectal cancer patients
|Mlecnik B,Tosolini M,Charoentong P,Kirilovsky A,Bindea G,Berger A,Camus M,Gillard M,Bruneval P,Fridman WH,Pagès F,Trajanoski Z,Galon J||Gastroenterology (138:1429)||2010|
Coordination of intratumoral immune reaction and human colorectal cancer recurrence.
MA1-80231 was used in immunohistochemistry to study the correlation of intratumoral immune markers and human colorectal cancer escape
|Camus M,Tosolini M,Mlecnik B,Pagès F,Kirilovsky A,Berger A,Costes A,Bindea G,Charoentong P,Bruneval P,Trajanoski Z,Fridman WH,Galon J||Cancer research (69:2685)||2009|
CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8alpha; CD8b; CD8beta; Leu-2; Leu2 T-lymphocyte antigen; MAL; OKT8 T-cell antigen; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen
CD8; CD8A; CD8B; CD8B1; LEU2; LY3; LYT3; MAL; p32; P37